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  • Title: Cell-free expression of the beta-galactosidase gene: a model system to study the effects of nucleotide analogs on transcription-translation.
    Author: Zimmer M, Scheit KH.
    Journal: Nucleic Acids Symp Ser; 1981; (9):225-8. PubMed ID: 6795597.
    Abstract:
    A cell-free system for the expression of the beta-galactosidase gene was employed to study the effects of the UTP and CTP analogs: s2UTP, s2CTP, f5UTP and rTTP on transcription-translation. From the analogs investigated, only rTTP turned out to be able to substitute UTP in the cell-free synthesis of beta-galactosidase. In case of the other analogs listed above, the incorporation of even a small fraction of analog into rRNA resulted in drastic inhibition of beta-galactosidase synthesis.
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