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  • Title: Comparison of o-octopamine and related phenylethanolamines as substrates for norepinephrine N-methyltransferase.
    Author: Fuller RW, Hemrick-Luecke SK, Midgley JM.
    Journal: Res Commun Chem Pathol Pharmacol; 1981 Aug; 33(2):207-13. PubMed ID: 6795705.
    Abstract:
    o-Octopamine was a substrate for rabbit adrenal norepinephrine N-methyltransferase with lower affinity than the position isomers m-octopamine and p-octopamine. The order of substrate affinity for monochloro or monohydroxy phenylethanolamines was para greater than meta greater than ortho. With phenylethanolamine and ring-hydroxylated phenylethanolamines, primary amines were better substrates than were N-methyl secondary amines. N-Methylation might be a metabolic pathway for o-octopamine, reported to occur in mammalian tissues.
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