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  • Title: Inhibition of purine nucleoside phosphorylase by 8-aminoguanosine: selective toxicity for T lymphoblasts.
    Author: Kazmers IS, Mitchell BS, Dadonna PE, Wotring LL, Townsend LB, Kelley WN.
    Journal: Science; 1981 Dec 04; 214(4525):1137-9. PubMed ID: 6795718.
    Abstract:
    The guanosine analog 8-aminoguanosine is an effective inhibitor of the purine degradative enzyme purine nucleoside phosphorylase, both in vitro and in intact lymphoid cells. In a human lymphoblast tissue culture system, 8-aminoguanosine, in combination with low concentrations of 2'-deoxyguanosine, causes toxicity toward T cells but not B cells. The selective T cell toxicity correlates with increased accumulation of deoxyguanosine triphosphate in the treated T lymphoblasts.
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