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  • Title: S-Adenosylhomocysteine hydrolase activity in a lymphoblastoid cell line from a patient with adenosine deaminase dificiency disease.
    Author: Tsuchiya S, Nakae S, Konno T, Tada K.
    Journal: J Inherit Metab Dis; 1981; 4(4):197-201. PubMed ID: 6796770.
    Abstract:
    S-Adenosylhomocysteine (S-AdoHcy) hydrolase activity in a lymphoblastoid cell line from a patient with adenosine deaminase deficiency disease (ADA(-)LCL) was found to be approximately 60% of that in ADA (+)lymphoblastoid cell lines. S-AdoHcy hydrolase of ADA(-)LCL was more sensitive to inhibition by 2'-deoxyadenosine as compared with that of ADA(+)LCL. The inhibitory effect of 2'-deoxyadenosine was evident in cell growth and immunoglobulin production of lymphoblastoid cell lines.
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