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  • Title: [On the biological action of transition metal complexes. 2. The antiviral activity of 4-methyl-2-amino-pyridine-palladium-chloride (IV)].
    Author: Tonew M, Tonew E, Schröer HP, Heyn B.
    Journal: Zentralbl Bakteriol Mikrobiol Hyg A Med Mikrobiol Infekt Parasitol; 1981; 249(4):421-30. PubMed ID: 6797148.
    Abstract:
    4-methyl-2-amino-pyridine-palladiumchlorid (IV) showed an inactivation of cell-free enveloped DNA and RNA viruses in serum-free saline such as vaccinia, pseudorabies, herpes type 1, Newcastle disease and influenza virus A/fowl plague, human influenza type A and B and vesicular stomatitis viruses, and adenovirus, a naked DNA virus, too. Picorna viruses were not inactivated, the inactivation of other viruses failed in medium with 10% serum. However the replication of enveloped viruses as checked with vaccinia and fowl plague viruses was inhibited, also when the compound was present only for 1 h after infection. Contrary to this the multiplication of adenovirus was depressed only with 90%. For the inactivation of viruses high concentrations were necessary than for the inhibition of replication. Therefore more than one kind of mode of action have to be taken into consideration.
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