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  • Title: Fredericamycin A, a new antitumor antibiotic. I. Production, isolation and physicochemical properties.
    Author: Pandey RC, Toussaint MW, Stroshane RM, Kalita CC, Aszalos AA, Garretson AL, Wei TT, Byrne KM, Geoghegan RF, White RJ.
    Journal: J Antibiot (Tokyo); 1981 Nov; 34(11):1389-401. PubMed ID: 6798004.
    Abstract:
    A new antitumor antibiotic, fredericamycin A (FCRC-A48, NSC-305263), has been isolated from a strain of Streptomyces griseus (FCRC-48). Based on its unique ultraviolet-visible spectrum, infrared spectrum, proton and carbon-13 nuclear magnetic resonance spectra and mass spectra, it is judged to be a novel acid-base indicator type of compound. Its production, isolation and physicochemical properties are discussed. The isolation, ultraviolet-visible spectrum and some biological properties of two minor components, fredericamycin B and fredericamycin C, are also described.
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