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  • Title: Calcium dependency of potassium-stimulated thyrotropin-releasing hormone secretion from rat neurohypophysis in vitro.
    Author: Lackoff A, Jackson IM.
    Journal: Neurosci Lett; 1981 Dec 11; 27(2):177-81. PubMed ID: 6798509.
    Abstract:
    The role of Ca2+ on the K+ -stimulated release of thyrotropin-releasing hormone (TRH) from rat neurohypophysis, stalk median eminence (SME) and hypothalamic fragments in vitro was studied. High K+ (50 mM) caused a significant increase (2-6-fold) in TRH release from all three tissues, (P less than 0.05-0.01), and this effect was inhibited (by 62-80%) on removing Ca2+ (1.8 mM) from the medium (P less than 0.01). The calcium dependency of the TRH response to a membrane depolarizing stimulus (high K+) is consistent with TRH release occurring by a neurosecretory process from the neurophypophysis, as well as from hypothalamic tissue.
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