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  • Title: Glycyrrhizin inhibits prostaglandin E2 production by activated peritoneal macrophages from rats.
    Author: Ohuchi K, Kamada Y, Levine L, Tsurufuji S.
    Journal: Prostaglandins Med; 1981 Nov; 7(5):457-63. PubMed ID: 6798590.
    Abstract:
    Glycyrrhizin was found to inhibit prostaglandin E2 production by activated rat peritoneal macrophages. Preincubation of the cells with glycyrrhizin increases its inhibitory effectiveness. Glycyrrhetinic acid, the aglycone of glycyrrhizin, at a dose of 100 microgram per ml also inhibited prostaglandin E2 production, but the inhibition was considered to be attributable to a toxic effect on the cells since more than 30% of the cells were detached from the dish during the 8 hr incubation period. In contrast, glycyrrhizin did not detach the cells from the dish at doses up to 3 mg per ml. Release of [3H]arachidonic acid from prelabeled cells was also inhibited by glycyrrhizin. It is likely that anti-inflammatory activity of glycyrrhizin depends at least in part on its inhibitory effect of the production of prostaglandin E2.
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