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  • Title: Evidence that the repair deficient mei-9a female in Drosophila melanogaster is a strong potentiator of chromosome loss induced in the paternal genome by dimethylnitrosamine.
    Author: Zimmering S, Hartmann AW, Cooper SF.
    Journal: Environ Mutagen; 1980; 2(2):187-90. PubMed ID: 6799290.
    Abstract:
    From mating of Xc2/BsYy+ males treated or not with 2.5 mM DMN (dimethylnitrosamine) with repair-deficient mei-9a females or with ordinary females, induced frequencies of observed (recovered) chromosome loss were 3.69% and 0.65% and inferred (non-recovered) ring-X loss based on shifts in sex ratio (male male/female female) was 47.9% and 9.4%, respectively. Results indicate that the mei-9a female is a strong potentiator of DMN-induced chromosome damage in sperm and suggest that DMN-induced chromosome lesions are produced in substantially higher frequency in treated sperm than deducible after crosses with repair-efficient females.
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