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  • Title: Glycosaminoglycan content and cell density of rabbit articular cartilage in experimental lipoarthrosis.
    Author: Stockwell RA, Sprinz R.
    Journal: J Anat; 1981 Sep; 133(Pt 2):309-15. PubMed ID: 6800995.
    Abstract:
    Glycosaminoglycan content and cell density of articular cartilage have been studied quantitatively in the adult rabbit in experimental lipoarthrosis. On the fourth day after injection of non-radioactive or tritium-labelled glyceryl trioleate into the synovial cavity of the knee joint, femoral condylar cartilage shows no change in cellularity. There is a 35% loss of chondroitin sulphate from the matrix, but little change in keratansulphate. The results are not affected by the presence or absence of radioactive isotope in the lipid: possible mechanisms accounting for glycosaminoglycan loss are discussed.
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