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  • Title: The effect of carbidopa and benserazide on human plasma 5-hydroxytryptophan levels.
    Author: Young SN, Gauthier S, Chouinard G, Anderson GM, Purdy WC.
    Journal: J Neural Transm; 1982; 53(1):83-7. PubMed ID: 6801200.
    Abstract:
    Peripheral aromatic amino acid decarboxylase inhibitors increase human plasma 5-hydroxytryptophan (5-HTP) levels. However the 5-HTP, which is synthesized in the intestine, is not present in a sufficient quantity to influence brain 5-HT to any significant degree. Thus, peripheral decarboxylase inhibitors are unlikely to affect brain 5-HT function via 5-HTP which is synthesized peripherally.
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