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  • Title: Inhibition of the plasminogen activator urokinase by alpha-tocopherol.
    Author: Ogston D.
    Journal: Acta Haematol; 1982; 67(2):114-8. PubMed ID: 6801892.
    Abstract:
    alpha-Tocopherol (vitamin E) inhibited the activity of urokinase on fibrin plates and on the amidolytic substrate S-2444 in a concentration- and time-dependent manner. Inhibition was not removed by dialysis. In the presence of dilutions of plasma, protein-containing fractions of gel-filtered plasma, or bovine serum albumin, the inhibition of urokinase by alpha-tocopherol was abolished. Urokinase activity was not inhibited by phytol, menadione or hydroquinone.
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