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  • Title: Intestinal and hepatic morphine glucuronidation in immature and pregnant rats.
    Author: Pacifici GM, Rane A.
    Journal: Dev Pharmacol Ther; 1981; 3(3):160-7. PubMed ID: 6802622.
    Abstract:
    The glucuronyl transferase activity was measured in the rat liver and intestinal microsomes during the neonatal development and pregnancy using 14C-morphine as substrate. During development the hepatic glucuronyl transferase activity increased 16-fold from day 1 after birth until a maximum of 9.97 nmol/min/mg on day 20. The enzyme activity in intestinal microsomes increased only 4-fold from day 1 to 0.19 nmol/min/mg on day 30. After the peak activities were reached, there was a continuous decrease in the glucuronyl transferase activities. During pregnancy the glucuronyl transferase activity increased significantly in the liver while no change was observed in the intestinal microsomal fraction.
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