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  • Title: Abstinence-induced changes in plasma apolipoprotein levels of alcoholics.
    Author: Barboriak JJ, Alaupovic P, Cushman P.
    Journal: Drug Alcohol Depend; 1981 Dec; 8(4):337-43. PubMed ID: 6802625.
    Abstract:
    Plasma lipids, including total cholesterol, plasma triglycerides, high density lipoprotein cholesterol and several apolipoproteins were measured in eight otherwise healthy male alcoholics at the beginning and during a 4-week inpatient abstinence treatment program. The initial triglyceride and apolipoprotein A-11 levels were higher and apolipoprotein B was lower in alcoholics than in 12 nondrinking control subjects. During the alcohol abstinence there was a parallel fall in the levels of high density lipoprotein cholesterol, and apolipoproteins A-I and A-II and a rise in apolipoprotein B. The changes in apolipoproteins C-III and E were less consistent. These findings suggest that, even in otherwise healthy alcoholics, elevated levels of apolipoproteins A-I and A-II on admission are ameliorated during abstinence of several weeks.
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