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  • Title: Failure of the fluorescent antibody reaction to identify penicillinase-producing gonococci.
    Author: Waitkins SA, Anderson RD.
    Journal: J Clin Pathol; 1982 Feb; 35(2):215-8. PubMed ID: 6802878.
    Abstract:
    The fluorescent antibody test is now widely used to confirm the identity of Neisseria gonorrhoeae but may fail to identify penicillinase-producing strains (PPNG). This problem arises when conjugates are used that incorporate only gonococci that are not penicillinase-producers. We have shown that conjugates prepared from mixtures of PPNG and non-penicillinase producing gonococci give good fluorescent reactions. This difference in the reactions of PPNG strains is clearly related to their penicillinase-producing abilities, further study of the antigenic relation between penicillinase production and the antigenic structure of N gonorrhoeae is evidently required.
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