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  • Title: Recent findings in understanding the biological function of vitamin K.
    Author: Uotila L, Suttie JW.
    Journal: Med Biol; 1982 Feb; 60(1):16-24. PubMed ID: 6803084.
    Abstract:
    Vitamin K is required for the posttranslational modification of liver precursors of prothrombin, blood coagulation Factors VII, IX, and X and additional proteins of undetermined functions in plasma and other tissues. This modification involves the formation of gamma-carboxyglutamic acid, an acidic amino acid needed for the interaction of these proteins with calcium ions. The vitamin is a cofactor of a unique microsomal carboxylase which requires the reduced form of vitamin K, CO2, and molecular oxygen. The vitamin is apparently oxidized to its 2,3-epoxide during the carboxylation reaction. Liver microsomes also contain an enzyme which catalyzes the reduction of the epoxide to the vitamin, vitamin K epoxide reductase, and a number of vitamin K reductases. The epoxide reductase appears to be the site of the anticoagulant action of 4-hydroxycoumarins, commonly used as oral anticoagulants.
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