These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Raised plasma oestrogens in infertile men with elevated levels of FSH.
    Author: Wu FC, Swanston IA, Baird DT.
    Journal: Clin Endocrinol (Oxf); 1982 Jan; 16(1):39-47. PubMed ID: 6804135.
    Abstract:
    In twenty oligospermic or azoospermic patients with elevated plasma FSH, the mean concentrations of plasma oestrone sulphate (843 +/- 233 pg/ml), oestrone (54 +/- 10.4 pg/ml) and oestradiol (46.6 +/- 12.6 pg/ml) were found to be significantly higher than in twenty-one normal fertile men of comparable age (593 +/- 220 pg/ml, 40.6 +/- 8.8 pg/ml and 33.1 +/- 10.9 pg/ml respectively). SHBG binding capacity was elevated in the infertile group (infertile 3.35 +/- 0.82 x 10(-8) M/l v. normal 2.76 +/- 0.89 x 10(-8) M/l) but the total plasma testosterone concentrations were comparable (infertile 5435 +/- 1578 pg/ml v. normal 5046 +/- 1102 pg/ml). Evidence was cited to support the view that Sertoli cells, in response to an unphysiological FSH stimulation, are a likely source of excessive oestrogen production. The possible significance of increased intra-testicular and circulating oestrogen in the altered state of testicular steroidogenic function in men with primary seminiferous tubular defects was discussed.
    [Abstract] [Full Text] [Related] [New Search]