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  • Title: Prevention of glucose-induced insulin secretion by lipoxygenase inhibitor.
    Author: Yamamoto S, Nakadate T, Nakaki T, Ishii K, Kato R.
    Journal: Eur J Pharmacol; 1982 Feb 26; 78(2):225-7. PubMed ID: 6804249.
    Abstract:
    Glucose-induced insulin secretion was investigated using isolated pancreatic islets of rats. The phospholipase A2 inhibitors. p-bromophenacyl bromide (0.1 mM) and mepacrine (0.1 mM) inhibited glucose-induced insulin secretion. Indomethacin (5 microM), a cyclooxygenase inhibitor, failed to inhibit glucose-induced insulin secretion, while the lipoxygenase inhibitor nordihydroguaiaretic acid (0.1-0.2 mM) inhibited it. These results suggest that stimulation of phospholipase A2 and a product(s) formed by the lipoxygenase pathway play an important role in the glucose-induced insulin secretion.
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