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  • Title: Aminergic receptors in Drosophila melanogaster: properties of [3H]dihydroergocryptine binding sites.
    Author: Dudai Y, Zvi S.
    Journal: J Neurochem; 1982 Jun; 38(6):1551-8. PubMed ID: 6804603.
    Abstract:
    [3H]Dihydroergocryptine ([3H]DHE) binds to a particulate preparation from Drosophila melanogaster heads at a level of 2.4 +/- 0.4 pmol/mg protein, with an apparent dissociation constant of 2.0 +/- 0.5 nM. The binding sites are inactivated by heat, pronase treatment, and sulfhydryl and disulfide reagents. [3H]DHE binding is inhibited by low concentrations of serotonergic and alpha-adrenergic ligands. The specificity of the binding sites, as revealed by displacement studies, differs from that of [3H]DHE binding sites in various vertebrate tissues. The [3H]DHE binding sites may correspond to serotonergic receptors, and possibly, to additional classes of receptors for putative neurotransmitters in Drosophila.
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