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  • Title: The effect of food on the oral absorption of penicillin V preparations in children.
    Author: Finkel Y, Bolme P, Eriksson M.
    Journal: Acta Pharmacol Toxicol (Copenh); 1981 Oct; 49(4):301-4. PubMed ID: 6805255.
    Abstract:
    The oral absorption of pc V in different preparations, given at various times before and after a meal, was investigated in children with upper respiratory infections. The best absorption with respect to peak concentration was observed when potassium pc V (Calciopen) was given after at least two hours of fasting with no food intake within the following hour. Shorter periods of fasting (1, 1/2, 0 hrs) before drug intake resulted in significantly lower plasma concentrations. When drug intake was followed by a meal, the absorption was also decreased to some extent. When pc V was given in an oil suspension (Fenoxypen), or in a small volume (Roscopenin) together with a meal, the peak concentration was significantly lower than when pc V was given in an aqueous solution with a larger volume (Calciopen).
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