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  • Title: Demeclocycline in the prophylaxis of self-induced water intoxication.
    Author: Nixon RA, Rothman JS, Chin W.
    Journal: Am J Psychiatry; 1982 Jun; 139(6):828-30. PubMed ID: 6805340.
    Abstract:
    Demeclocycline, a competitive inhibitor of antidiuretic hormone at renal tubules, was studied in a patient with the syndrome of psychosis, psychogenic polydipsia, and episodic water intoxication. Under double-blind, placebo-controlled conditions, demeclocycline substantially reduced the severity and frequency of hyponatremic episodes.
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