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  • Title: Monensin inhibits synthesis of proteoglycan, but not of hyaluronate, in chondrocytes.
    Author: Mitchell D, Hardingham T.
    Journal: Biochem J; 1982 Jan 15; 202(1):249-54. PubMed ID: 6805469.
    Abstract:
    Monensin (10nm-1mum) inhibited the incorporation of [(35)S]sulphate and [(3)H]glucosamine into proteoglycans by rat chondrosarcoma cells, but the incorporation of [(3)H]glucosamine into hyaluronate was unaffected. The results suggest that hyaluronate synthesis occurs in a cell compartment separate from chondroitin sulphate synthesis.
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