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  • Title: The red blood cell/plasma lithium ratio: marker of biological heterogeneity within bipolar affective illness?
    Author: Rihmer Z, Arató M, Szentistványi I, Bánki CM.
    Journal: Psychiatry Res; 1982 Apr; 6(2):197-201. PubMed ID: 6806837.
    Abstract:
    The red blood cell/plasma concentration ratio (LR) was studied in 45 female patients with bipolar affective illness who responded to prophylactic lithium treatment. Patients were subdivided according to bipolar I vs. bipolar II diagnosis and presence vs. absence of a family history of affective illness. Mean LRs were significantly higher in bipolar II patients and in those with a positive family history of affective illness, but there was no relationship between diagnosis and family history. Results indicate that LR is genetically controlled and may be a biological marker distinguishing bipolar I and bipolar II patients, and also patients with positive or negative family history of affective illness.
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