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  • Title: Alteration in the plasma testosterone: estradiol ratio: an alternative to the inhibin hypothesis.
    Author: Sherins RJ, Patterson AP, Brightwell D, Udelsman R, Sartor J.
    Journal: Ann N Y Acad Sci; 1982; 383():295-306. PubMed ID: 6807167.
    Abstract:
    The data suggest that in the absence of the testis: (1) testosterone can maintain both FSH and LH concentrations chronically within the physiological range; (2) that estradiol preferentially suppresses plasma LH concentration, indicating that the androgenic component of testosterone modulates FSH secretion; and (3) that subphysiological testosterone concentrations accompanied by physiological estradiol levels permit FSH to escape to midcastrate levels while maintaining LH concentration at intact levels. An alteration in the testosterone: estradiol ratio can account for a selective FSH elevation when testosterone production is low. The data provide an alternative explanation for the inhibin phenomenon.
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