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  • Title: Batch-swirl method for detoxification of isopropyl myristate used for sterility testing of oils and ointments: membrane selection.
    Author: Placencia AM, Oxborrow GS, Danielson JW.
    Journal: J Pharm Sci; 1982 Jun; 71(6):714-5. PubMed ID: 6808114.
    Abstract:
    A 1-hr batch-swirl method was developed for the preparation of isopropyl myristate to be used in the sterility testing of oils and ointments. The method is simpler and faster than that in USP XX. Flow rates of various membrane filters were tested. Cellulose acetate filters increased the filtration rate of oils and ointments and, thus, reduced the exposure time of possible microbial contaminants to the toxicity of isopropyl myristate.
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