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  • Title: Pinazepam: a precursor of N-desmethyldiazepam.
    Author: Pacifici GM, Placidi GF, Fornaro P, Gomeni R.
    Journal: Eur J Clin Pharmacol; 1982; 22(3):225-8. PubMed ID: 6809477.
    Abstract:
    The plasma profile of a single oral dose of pinazepam 10 mg was studied in 6 healthy male volunteers, aged 26 to 31 years. The concentrations of the parent compound and of its metabolite in plasma were measured by gas-chromatography. The peak plasma levels of pinazepam was 36.8 +/- 5.1 ng/ml and of N-desmethyldiazepam 150 +/- 13.3 ng/ml. The plasma concentration of the metabolite become higher than that of the parent compound shortly after administration, suggesting that pinazepam acts as a prodrug.
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