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  • Title: Intravenous nitroglycerin in acute infarction. Part II.
    Author: Valladares BK, Lemberg L.
    Journal: Heart Lung; 1982; 11(5):490-3. PubMed ID: 6809697.
    Abstract:
    Intravenous nitroglycerin is helpful as an adjunct to the judicious use of diuretics in the management of CHF complicating an acute MI. The clinical end point when using intravenous nitroglycerin is a reduced LVEDP, 16 mm Hg, measured either by PA diastolic pressure or PCWP, provided peripheral perfusion is not compromised, i.e., as blood pressure adequate for peripheral needs (absence of signs of hypovolemic shock). The reduction in cardiac work plus the improvement in coronary flow to the ischemic area can help reduce infarct size, especially if intravenous nitroglycerin is started within the first 6 hours of the onset of an acute MI.
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