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  • Title: Immunochemical studies of high and low molecular forms of urokinase.
    Author: Sumi H, Toki N, Maehara S, Kosugi T, Akazawa K, Matsuo O, Mihara H.
    Journal: Acta Haematol; 1982; 67(4):263-7. PubMed ID: 6810625.
    Abstract:
    The immunochemical properties of high and low molecular forms of urokinase (HMW-UK, MW 53,000, 124,000 IU/mg protein; LMW-UK, MW 32,000, 230,000 IU/mg protein) were studied with specific antisera against the functionally active heavy chain (H chain, MW 31,000, 201,000 IU/mg protein) and the light chain (L chain, MW 18,000) of HMW-UK. Using a double immunodiffusion technique, LMW-UK did not demonstrate L chain antigenicity in the molecule. Anti-L-chain serum exerted no effect on LMW-UK and the H chain, but anti-H-chain serum strongly inhibited the fibrinolytic activity of all the active enzymes (HMW-UK, LMW-UK, and H chain). Anti-L chain serum was found to exert an antifibrinolytic effect on HMW-UK.
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