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  • Title: Growth inhibition of a prostate tumor by alpha-difluoromethylornithine and by cyclophosphamide.
    Author: Heston WD, Kadmon D, Fair WR.
    Journal: Cancer Lett; 1982; 16(1):71-79. PubMed ID: 6811130.
    Abstract:
    The effects of the ornithine decarboxylase suicide substrate, difluoromethylornithine (DFMO), and of cyclophosphamide, individually and in combination, on the growth of the R3327MAT-Lu prostate derived tumor were determined. DFMO decreased the growth rate and resulted in a 75% reduction in DNA content compared to the control group. Cyclophosphamide produced a greater inhibition of growth and resulted in a 96% reduction in DNA content relative to the control. DFMO in combination with cyclophosphamide provided no greater inhibition of tumor growth than that of cyclophosphamide as a single agent. Further, in the schedule used in this experimental protocol the toxicity to the host of the drug combination was additive.
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