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  • Title: [The use of amikacin in the treatment of endometritis caused by Pseudomonas aeruginosa in mares].
    Author: van Dyk E, Immelman A, van Heerden JS.
    Journal: J S Afr Vet Assoc; 1982 Jun; 53(2):124-6. PubMed ID: 6811742.
    Abstract:
    After isolation of Pseudomonas aeruginosa from endometrial biopsies of 6 mares they were treated with amikacin sulphate. Three were treated by intra-uterine application of the drug, in one the drug was given by intramuscular injection, in another the intravenous route was used while in the last mare simultaneous local and intravenous treatment was applied. An intra-uterine Tris-EDTA instillation preceeded the uterine amikacin instillations to aid in the breakdown of the capsule around the bacterium. Serum concentrations of amikacin were determined after intravenous and intramuscular administration. The highest concentration of 15 microgram/ml was reached 1 hour after intravenous injection. After 12 hours the blood concentration was below the therapeutic level. To maintain effective levels injection must be repeated 6-8 hourly. All mares treated by the intra-uterine or intravenous routes recovered. The importance of obtaining cultures from uterine biopsies is stressed as Pseudomonas was cultured only once from the conventional cervical swab while the other 5 mares had negative cervical swabs.
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