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  • Title: Early onset life-threatening myelosuppression after low dose of intravesical thiotepa.
    Author: Agnelli G, de Cunto M, Gresele P, del Favero A.
    Journal: Postgrad Med J; 1982 Jun; 58(680):380-1. PubMed ID: 6812036.
    Abstract:
    Intravesical instillation of thiotepa is a popular treatment for localized bladder carcinoma. The drug can enter the systemic circulation, and such absorption may be enhanced by extensive tumour infiltration or by a recent tumour resection. A case is reported of early onset life-threatening pancytopenia following an unusually low dose of the drug in a patient who had undergone a recent tumour resection.
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