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  • Title: Drug metabolism in a reconstituted system by diabetes-dependent hepatic cytochrome P-450.
    Author: Past MR, Cook DE.
    Journal: Res Commun Chem Pathol Pharmacol; 1982 Jul; 37(1):81-90. PubMed ID: 6812187.
    Abstract:
    Previous studies have shown that diabetes induces a unique 52,000 molecular weight cytochrome P-450 in rat hepatic microsomes. In the present study, the catalytic properties of the two major purified diabetic P-450s were contrasted to those of the major normal purified P-450 in a reconstituted drug metabolizing system. the greatest rate of aniline hydroxylation was catalyzed by the 52,000 molecular weight diabetic P-450 (7-fold greater than normal). This same diabetic P-450 also catalyzed a slower rate of ethylmorphine N-demethylation compared to the major normal and the other diabetic P-450. These results indicate that the catalytic properties of this diabetes-dependent P-450 are responsible for the substrate-specific alterations in drug metabolism observed in both liver microsomes and isolated perfused liver from diabetic rats.
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