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  • Title: Valproic acid and immune thrombocytopenia.
    Author: Barr RD, Copeland SA, Stockwell ML, Morris N, Kelton JC.
    Journal: Arch Dis Child; 1982 Sep; 57(9):681-4. PubMed ID: 6812506.
    Abstract:
    During the course of a prospective serial study over a period of one year, findings compatible with immune-mediated thrombocytolysis accompanied the administration of valproic acid in about half of 45 children with epilepsy. Thrombocytopenia occurred in 15 and neutropenia in 12 patients, but was transient and self-limiting in each. The association is probably one of cause and effect, and it may reflect the structural similarity between valproic acid and constituents of cell membranes.
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