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  • Title: Localization of cyclo-oxygenase and thromboxane synthetase in human platelet intracellular membranes.
    Author: Carey F, Menashi S, Crawford N.
    Journal: Biochem J; 1982 Jun 15; 204(3):847-51. PubMed ID: 6812567.
    Abstract:
    Platelet mixed membrane fractions can be separated into discrete vesicle subpopulations of surface and intracellular origin. Intracellular membrane vesicles are the predominant site of phospholipid-modifying enzymes that liberate arachidonic acid. We report the selective enrichment in intracellular membranes of cyclo-oxygenase and thromboxane synthetase activities. Surface membrane fractions show no such enrichment. These results suggest that a sequence of activities leading to the biosynthesis of thromboxane from arachidonate is associated with the intracellular membrane elements known as dense tubular membranes.
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