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  • Title: Disturbance of pulmonary prostaglandin metabolism in fetuses of alloxan-diabetic rabbits.
    Author: Tsai MY, Schallinger LE, Josephson MW, Brown DM.
    Journal: Biochim Biophys Acta; 1982 Aug 18; 712(2):395-9. PubMed ID: 6812641.
    Abstract:
    [14C]Arachidonic acid conversion in lung homogenates of 28-day fetuses from control and alloxan-diabetic rabbits was studied. The major metabolites were 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid and prostaglandin E2. Small amounts of 6-ketoprostaglandin F1 alpha, prostaglandin F2 alpha, and thromboxane B2 were also observed. Lung homogenates from fetuses of alloxan-diabetic rabbits convert significantly less [14C]arachidonic acid to prostaglandin E2, whereas all other metabolites were present in similar quantities compared to fetuses of non-diabetic rabbits. These studies suggest that the decreased arachidonic acid conversion to prostaglandin E2 could be partially responsible for the functional delay of lung maturation in offspring of alloxan-diabetic rabbits.
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