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  • Title: HLA haplotype study of 53 juvenile insulin-dependent diabetic (I.D.D.) families.
    Author: Contu L, Deschamps I, Lestradet H, Hors J, Schmid M, Busson M, Benajam A, Marcelli-Barge A, Dausset J.
    Journal: Tissue Antigens; 1982 Aug; 20(2):123-40. PubMed ID: 6814007.
    Abstract:
    R4 heterozygotes was observed. By contrast, the observed frequency of patients homozygous for DR3 or DR4 was not increased, but even slightly decreased. The data support a model of inheritance comprising at least two closely linked specifically "diabetic" loci (most of the time marked by B18, BfF1, DR3 and B15, BfS, DR4) and a non-specifically "diabetic" haplotype favouring auto-immunisation (most of the time marked by B8, BfS, DR3). This model is discussed in the light of the presented data and of those of the literature.
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