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  • Title: Inhibition of DNA synthesis does not influence the H1 histone synthesis in Tetrahymena pyriformis.
    Author: Klenow S.
    Journal: Biochim Biophys Acta; 1982 Oct 29; 699(1):49-52. PubMed ID: 6816282.
    Abstract:
    In the protozoan Tetrahymena pyriformis the DNA synthesis is stopped immediately and completely after addition of one of the two DNA synthesis inhibitors methotrexate + uridine and hydroxyurea to a cell suspension. However, the present experiments show, that the accumulation of labeled H1 histone in the inhibited cells is almost totally unaffected for more than two-thirds of a cell cycle after addition of either inhibitor.
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