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  • Title: [Effect of thyroliberin on neurons of the sensorimotor cortex].
    Author: Kozhechkin SN.
    Journal: Biull Eksp Biol Med; 1982 Oct; 94(10):46-8. PubMed ID: 6816310.
    Abstract:
    The effect of thyroliberin (thyrotropin-releasing hormone) on extracellularly recorded spontaneous activity of sensorimotor cortical neurons was studied in experiments on non-anesthetized rabbits. Thyroliberin injected intravenously in doses of 0.1-7.0 mg/kg had an excitatory effect on the cortical neurons. In contrast, thyroliberin had a depressant effect when applied microiontophoretically to individual neurons. It is concluded that the excitatory effect of thyroliberin on the cortex after systemic application is related to the facilitation of subcortical-cortical activating influences. Extracortical receptors of the excitatory type are likely to be responsible for the main central-stimulating properties of thyroliberin.
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