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  • Title: The effects of sodium nitroprusside on cerebral blood flow and cerebral venous blood gases. I. Observations in awake man during and following moderate blood pressure reduction.
    Author: Henriksen L, Paulson OB, Lauritzen M.
    Journal: Eur J Clin Invest; 1982 Oct; 12(5):383-7. PubMed ID: 6816608.
    Abstract:
    Cerebral blood flow (CBF) and cerebral venous blood gases were studied in seven patients before, during and after intravenous sodium nitroprusside infusion. The 133Xe intra-arterial injection method was used for the CBF measurements. A dose of sodium nitroprusside (mean 1.0 mg, mean infusion time 20 min), which reduced mean arterial blood pressure by a mean of 17%, resulted in a 13% decrease in CBF (P less than 0.05). Measurements obtained 5 and 20 min after termination of the sodium nitroprusside infusion showed no signs of a hyperaemic rebound effect. Arterial PCO2, metabolic rate of oxygen, arterio-venous oxygen difference and venous PO2 remained unchanged during and after infusion. It is concluded that sodium nitroprusside has a minor effect on cerebral haemodynamics, an effect that might be mediated by the sympathetic nervous system.
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