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  • Title: [The histogenetic significance of dysplastic lesions of the cervix (author's transl)].
    Author: Minh HN, Smadja A, Orcel L.
    Journal: J Gynecol Obstet Biol Reprod (Paris); 1978 Apr; 7(3):387-98. PubMed ID: 681694.
    Abstract:
    From the morphological studies that they have carried out the authors describe dysplasias of the cervix of the uterus as a collection of lesions developed from the vestigial cells which are situated at the endo-exocervical junction. The embryological origin of this junction is the sinus. These dysplasias consist of cells with basophil cytoplasm with edges that are not sharp. These form streams which run from the external os of the cervix towards the endocervix, where they replace and disturb the cylindrical epithelium wherever they meet it. These lesions may take on two forms: regular or irregular according to the degree of nucleo-cytoplasmic disharmony. The slow and insidious evolution of these lesions must be distinguished from dystrophic endocervical lesions which are caused by a disturbance in the nutrition of the tissues, which itself is of hormonal or inflammatory origin, and from exocervical lesions which, in common with all lesions of the malpighian mucosa, can undergo atypical scarring.
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