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  • Title: Effect of continuous light on the incidence of 9,10-dimethyl-1,2-benzanthracene induced mammary tumors in female Holtzman rats.
    Author: Kothari LS, Shah PN, Mhatre MC.
    Journal: Cancer Lett; 1982 Sep; 16(3):313-7. PubMed ID: 6817910.
    Abstract:
    The pineal has been recently implicated in mammary tumorigenesis. Effect of physiological pinealectomy brought about by subjecting female Holtzman rats to permanent lighting (24 h/day) from birth was studied on the incidence of 9,10-dimethyl-1,2-benzanthracene (DMBA) induced mammary tumors. The incidence of adenocarcinoma was 95% in animals maintained in continuous photoperiod in contrast to that (60%) observed in control animals maintained on a light/dark (10/14 h) schedule. Further, the latency period of tumor appearance (61.5 +/- 9 days) in the former group was found to be significantly shorter than that seen in the latter group (93.7 +/- 8.3 days). Explanations are offered for this difference in the observed incidence.
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