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  • Title: Effect of sex hormones on the activities of hepatic alcohol-metabolizing enzymes in male rats.
    Author: Teschke R, Heymann K.
    Journal: Enzyme; 1982; 28(4):268-77. PubMed ID: 6818024.
    Abstract:
    In mature male rats both estradiol administration as well as castration had a striking suppressive effect on the hepatic activity of the microsomal ethanol-oxidizing system, whereas alcohol dehydrogenase activity was increased under these experimental conditions. The castration effects on the activities of the alcohol-metabolizing enzymes could be completely prevented by the administration of testosterone. Therefore, these results indicate the sex-dependent nature of the hepatic microsomal ethanol-oxidizing system and alcohol dehydrogenase.
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