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  • Title: Gas chromatographic analysis of ketamine and norketamine in plasma and urine: nitrogen-sensitive detection.
    Author: Stiller RL, Dayton PG, Perel JM, Hug CC.
    Journal: J Chromatogr; 1982 Nov 12; 232(2):305-14. PubMed ID: 6818238.
    Abstract:
    A sensitive gas chromatographic method for quantitative analysis of ketamine and norketamine in human and animal biological fluids is described. The nitrogen-sensitive detection procedure used is more stable than electron-capture detection and reduced analysis time. The method used bromo-ketamine as an internal standard for quantitation and is linear from 10-25,000 ng/ml. No interferences were shown with drugs commonly associated with cardiac surgery with cardiopulmonary by-pass. This assay is sensitive, specific, using either native or derivatized drugs and can be used for routine analysis of ketamine and norketamine in plasma or urine.
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