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  • Title: Insulinotropic effects of exogenous phospholipase A2 and C in isolated pancreatic islets.
    Author: Yamamoto S, Nakaki T, Nakadate T, Kato R.
    Journal: Eur J Pharmacol; 1982 Dec 17; 86(1):121-4. PubMed ID: 6819152.
    Abstract:
    In isolated pancreatic islets of rats, exogenous phospholipase A2 produced concentration-dependent insulin secretion. p-Bromophenacyl bromide-treated enzyme no longer showed the insulinotropic effect. The insulinotropic effect of phospholipase A2 was inhibited by nordihydroguaiaretic acid (NDGA) and 1-phenyl-3-pyrazolidinone (Phenidone) but not by indomethacin. Exogenous phospholipase C also demonstrated a concentration-related insulinotropic effect. The phospholipase C-induced insulin secretion, however, was inhibited by none of the above inhibitors. These results indicate that a lipoxygenase product(s) is involved in the insulinotropic action of phospholipase A2.
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