These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of chloramphenicol on hepatic mitochondrial and microsomal functions in protein-energy malnourishment.
    Author: Thabrew MI, Emerole GO, Olorunsogo OO.
    Journal: Res Commun Chem Pathol Pharmacol; 1982 Dec; 38(3):481-95. PubMed ID: 6819616.
    Abstract:
    In both protein-energy malnourished (PEM) and normal rats, chloramphenicol (7.5 mg/kg) competitively inhibits the activities of aniline hydroxylase and p-aminopyrine N-demethylase. The decrease in enzyme activities was very much less in PEM rats. In both groups of animals, chloramphenicol also lowered the respiratory control ratio (RCR) of mitochondria. However, as with the microsomal function, the decrease in mitochondrial RCR in PEM rats (18.2%) was much less than that (45.8%) in normal rats. These results suggest that the toxic effects of chloramphenicol could be less in PEM conditions.
    [Abstract] [Full Text] [Related] [New Search]