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  • Title: Heterogeneity of lymphokine production by murine T-lymphocyte clones.
    Author: MacDonald HR, Glasebrook AL, Kelso A, Zubler RH.
    Journal: Ann Immunol (Paris); 1982; 133D(2):171-8. PubMed ID: 6819809.
    Abstract:
    The production of lymphokines by alloreactive murine T-lymphocyte clones was investigated. Clones derived by limiting dilution or by micromanipulation were stimulated with T-cell-depleted irradiated allogeneic spleen cells, and the resulting supernatants were assayed for interleukin-2 (IL-2), interferon-gamma (gamma-IFN), macrophage-activating factor (MAF), B-cell helper factor (BHF) or granulocyte/macrophage colony-stimulating factor (GM-CSF). Lymphokine production was found to be heterogeneous at the clonal level, with both cytolytic and non-cytolytic clones being able to produce some (or all) of the factors tested. Comparison of a large number of independently derived clonal supernatants allowed the separation of IL-2, BHF and GM-CSF from each other and from MAF and gamma-IFN; however, no dissociation between the latter 2 lymphokines was observed.
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