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  • Title: Glycosaminoglycans and neoplastic transformation.
    Author: Chiarugi VP.
    Journal: Anticancer Res; 1982; 2(5):275-81. PubMed ID: 6819811.
    Abstract:
    Two classes of mammalian glycosaminoglycans (GAGs) are distinguished: hyaluronic acid and chondroitin sulphate homopolymers, exhibiting identical repetitive building blocks, versus heparan and dermatan sulphate co-polymers, with differently substituted disaccharidic units. Evidence reported herein suggests that the latter compounds are positive co-factors of matrix assembly promoting the interaction of collagenous and non-collagenous proteins and inhibiting proteolytic activity. Homopolymers, on the contrary, are recognized as negative co-factors impairing the interaction of matrix proteins. The effect of GAGs on matrix assembly influences all the cell periphery because of trans-membrane relationships between submembranous cytoskeletal structures and the outer pericellular matrix. Molecular mechanisms involving GAGs in neoplastic transformation are proposed and discussed.
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