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  • Title: Immunological aspects of Behçet's and Vogt-Koyanagi-Harada's diseases.
    Author: Ohno S.
    Journal: Trans Ophthalmol Soc U K (1962); 1981 Sep; 101 (Pt 3)(3):335-41. PubMed ID: 6820735.
    Abstract:
    Immunogenetic studies showed that Behçet's disease has a primary association with HLA-B antigen (HLA-BW51) and the same association throughout the world, whereas, Vogt-Koyanagi-Harada's disease (VKH) is primarily associated with supertypic HLA-DR antigen (MT3), an HLA-D-linked B cell alloantigen in Japanese. Immunological investigation showed that the serum levels of gamma-interferon (IFN-gamma) were significantly increased in both Behçet's disease and VKH, IFN-gamma showed a significant decrease in the ocular exacerbation stage in Behçet's disease. The highest IFN titre was observed 1 to 2 months after the onset of the disease in VKH.
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