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  • Title: Contribution of a platelet component to endothelial prostacyclin production despite inhibition of platelet cyclooxygenase activity.
    Author: Czervionke RL, Hoak JC, Haycraft DL, Fry GL, Mann KG.
    Journal: Trans Assoc Am Physicians; 1982; 95():272-9. PubMed ID: 6820742.
    Abstract:
    Platelets aggregated with low concentrations of thrombin enhanced prostacyclin release from umbilical vein endothelium, which had an active cyclooxygenase. This result cannot be explained solely by an effect of thrombin on the endothelium or by transfer of the endoperoxide PGH2 from platelets to the endothelium. The quantity of prostacyclin released is sufficient to alter platelet adherence to umbilical vein endothelium in the presence of thrombin.
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