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Title: Active and passive mouse-protecting capacity of Pseudomonas aeruginosa protein vaccines. Author: Joó I, Stanislavsky ES, Zhvanetskaya MI, Mashilova GM, Gladus MA. Journal: Acta Microbiol Acad Sci Hung; 1982; 29(4):267-75. PubMed ID: 6821018. Abstract: Six different vaccines were prepared, each containing the soluble, practically lipopolysaccharide-free protein extract of 2 or 3 Pseudomonas aeruginosa strains. In active mouse protection tests the vaccines were shown to give protection against both homologous and heterologous serotype strains, and against strain PA-103 producing exotoxin A. In rabbits the vaccines were found to stimulate the production of protective antibodies demonstrable in a passive mouse protection test. The immune serum had a protective effect against the exotoxin A-producing strain PA-103, too. Toxicity of the vaccines was studied in mice (mouse weight gain test) and in rabbits (intracutaneous skin test and pyrogenicity). The vaccines were not or only slightly toxic.[Abstract] [Full Text] [Related] [New Search]